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The church exists because of a vow: in 1630, with plague killing roughly a third of Venice's population, the Republic's Senate promised to build a church dedicated to the Virgin Mary if the city was delivered from the epidemic. When the plague subsided the following year, construction began on the site chosen for its visibility from the water and its easy processional route from Piazza San Marco.
Baldassare Longhena, only 26 when he won the design competition, spent the rest of his working life on the project -- construction stretched over five decades, and Longhena died in 1682, five years before the church was finally consecrated in 1687. Its unusual octagonal plan and the massive stone buttresses supporting the dome were engineering choices as much as aesthetic ones: the church was built on more than a million wooden piles driven into the mud of the lagoon to support its weight.
The annual Festa della Madonna della Salute, held every November 21st since the year after the plague ended, has continued uninterrupted for nearly four centuries -- a pontoon bridge is built across the Grand Canal for the occasion, letting pilgrims walk from Piazza San Marco exactly as the original 1631 procession did.
The church remains an active place of worship and now shares its complex with a seminary, while the November pilgrimage continues to draw both religious visitors and Venetians marking the city's deliverance from one of its worst disasters.